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Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii

Received: 19 July 2016     Accepted: 25 August 2016     Published: 3 November 2016
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Abstract

Two new indole alkaloid derivatives namely Mostueatecine A (1), Mostueatecine B (2) and one new triterpene derivative Mostueatecine C (3) were isolated from the stem and leaves of Mostuea batesii, along with five known compounds: Camptothecine (4), β-amyrin-3-O-glucopyranoside (5), Oleanolic acid (6), 2α,3α,19α-trihydroxy-24-norurs-4(23),12-dien-28-oic acid (7) and Saccharose(8). The structures of these compounds were elucidated using a detailed analysis of their HRESI-MS, 1D and 2D NMR spectroscopic data. Some of these compounds were evaluated in vitro for their antimicrobial activities against a wide range of microorganisms. The results showed that none of them possess noticeable activity.

Published in Journal of Diseases and Medicinal Plants (Volume 2, Issue 6)
DOI 10.11648/j.jdmp.20160206.11
Page(s) 60-66
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Mostuea batesii, Loganiaceae, Indolic Alkaloids, Mostueatecine, Triterpenoids, Antimicrobial Activity

References
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[2] Burkill, H. M.The useful plants of West Tropical Africa. 2nd Edition.Volume 3, Royal Botanic Gardens, Kew, Richmond, United Kingdom. 857 1995.
[3] De Smet, P. A. G. M.Some ethnopharmacological notes on African hallucinogens. Journal of Ethnopharmacology. 50: 141–146. 1996.
[4] Neuwinger, H. D.; African traditional medicine: a dictionary of plant use and applications. Med. Pharm. Scientific, Stuttgart, Germany. 589. 2000.
[5] Dai, J. R.; Hallock, Y. F.; Cardellina, J. H.; Boyd, M. R.; 20-O-ßGlucopyranosylcamptothecin from Mostueabrunonis: A potential camptothecin pro-drug with improved solubility. J. Nat. Prod. 62: 1427-1429, 1999.
[6] Dzoyem, J. P.; Tangmouo, J. G.; Lonsi, D.; Etoa, F. X.; Lohoue, P. J.; In vitro. Antifungal Activity of extract and plumbagin from Diospyros crassIfloraHiern (Ebenaceae) Phytoter. Res. 14: 112 2007.
[7] Sun, Y. N.; Wang, C. L.; Zhang, N.; Wang, Z.; Liu, Z. L.; Liu, J. L.; Synthesis of tetrahydro-β-carbolinesfromphthalic anhydrides and tryptamineChinese Chemical Letters 25. 1503–1506. 2014
[8] Xuan, W. D.; Chen, H. S.; Du, J. L.; Liang, S.; Li, T. Z.; Cai, D. G.; Two new indole alkaloids from Nauclea officinalis. Journal of Asian Natural Products Research; 8: 719-722. 2008.
[9] Sun, J.; Lou, H.; Dai, S.; Xu, H.; Zhao, F.; Liu K. indole alkaloids from Nauclea officinalis with weak antimalarial activity. Phytochemistry 69, 1405-1419. 2007.
[10] Wang, M.; Kikuzaki, H.; Csiszar, K.; Boyd, C. D.; Maunakea, A.; Fong, S. F.; Ghai, G.; Rosen, R. T.; Nakatani, N.; Ho, C. T.Novel trisaccharide fatty acid ester identified from the fruits of Morinda citrifolia (Noni). J. Agric. Food Chem., 47(12): 4880. 1999.
[11] Noaki, K.; Hideki, O.;Fukushi, E.; Shuichi, O.; Kawa, J. Structural analysis of two trisaccharides isolated from fermented beverage of plant extract, Open Geoscience 1. 25-30. 2008.
[12] Rao, S. C.; Banji1, D.; Sandhya, S.; Mahesh, V. A study on the nutraceuticals from the genus Rumex Hygeia. J. D. Med. 3 (1), 2011, 76-88.
[13] Mahato, S. B; andKundu, A. P. 13C NMR spectra of pentacyclic triterpenoids a compilation and some salient features. Phytochemistry. 37, (6), 1517-1575. 1994.
[14] Fabry, W.; Okemo, P. O.; Ansorg, R. Antibacterial activity of East African medicinal plants. Journal of Ethnopharmacology. 60: 79-84. 1998.
[15] Njimoh, D. L.; Assob, J. C.; Mokake, S. E.; Nyahalah, D. J.; Yinda, C. K.; Sandjon, B. Antimicrobial activities of a plethora of medicinal plant extracts and hydrolates against human pathogens and their potential to reverse antibiotic resistance. International Journal of Microbiology: 15. 2015.
Cite This Article
  • APA Style

    Gompe Eric Gustave, Ouahouo Wache Blandine Marlyse, Mkounga Pierre, Tabouguia Merveille, Assob Nguedia Jules, et al. (2016). Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii. Journal of Diseases and Medicinal Plants, 2(6), 60-66. https://doi.org/10.11648/j.jdmp.20160206.11

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    ACS Style

    Gompe Eric Gustave; Ouahouo Wache Blandine Marlyse; Mkounga Pierre; Tabouguia Merveille; Assob Nguedia Jules, et al. Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii. J. Dis. Med. Plants 2016, 2(6), 60-66. doi: 10.11648/j.jdmp.20160206.11

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    AMA Style

    Gompe Eric Gustave, Ouahouo Wache Blandine Marlyse, Mkounga Pierre, Tabouguia Merveille, Assob Nguedia Jules, et al. Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii. J Dis Med Plants. 2016;2(6):60-66. doi: 10.11648/j.jdmp.20160206.11

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  • @article{10.11648/j.jdmp.20160206.11,
      author = {Gompe Eric Gustave and Ouahouo Wache Blandine Marlyse and Mkounga Pierre and Tabouguia Merveille and Assob Nguedia Jules and Clement Fotie Jean and Nkengfack Augustin Ephrem},
      title = {Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii},
      journal = {Journal of Diseases and Medicinal Plants},
      volume = {2},
      number = {6},
      pages = {60-66},
      doi = {10.11648/j.jdmp.20160206.11},
      url = {https://doi.org/10.11648/j.jdmp.20160206.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160206.11},
      abstract = {Two new indole alkaloid derivatives namely Mostueatecine A (1), Mostueatecine B (2) and one new triterpene derivative Mostueatecine C (3) were isolated from the stem and leaves of Mostuea batesii, along with five known compounds: Camptothecine (4), β-amyrin-3-O-glucopyranoside (5), Oleanolic acid (6), 2α,3α,19α-trihydroxy-24-norurs-4(23),12-dien-28-oic acid (7) and Saccharose(8). The structures of these compounds were elucidated using a detailed analysis of their HRESI-MS, 1D and 2D NMR spectroscopic data. Some of these compounds were evaluated in vitro for their antimicrobial activities against a wide range of microorganisms. The results showed that none of them possess noticeable activity.},
     year = {2016}
    }
    

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    T1  - Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii
    AU  - Gompe Eric Gustave
    AU  - Ouahouo Wache Blandine Marlyse
    AU  - Mkounga Pierre
    AU  - Tabouguia Merveille
    AU  - Assob Nguedia Jules
    AU  - Clement Fotie Jean
    AU  - Nkengfack Augustin Ephrem
    Y1  - 2016/11/03
    PY  - 2016
    N1  - https://doi.org/10.11648/j.jdmp.20160206.11
    DO  - 10.11648/j.jdmp.20160206.11
    T2  - Journal of Diseases and Medicinal Plants
    JF  - Journal of Diseases and Medicinal Plants
    JO  - Journal of Diseases and Medicinal Plants
    SP  - 60
    EP  - 66
    PB  - Science Publishing Group
    SN  - 2469-8210
    UR  - https://doi.org/10.11648/j.jdmp.20160206.11
    AB  - Two new indole alkaloid derivatives namely Mostueatecine A (1), Mostueatecine B (2) and one new triterpene derivative Mostueatecine C (3) were isolated from the stem and leaves of Mostuea batesii, along with five known compounds: Camptothecine (4), β-amyrin-3-O-glucopyranoside (5), Oleanolic acid (6), 2α,3α,19α-trihydroxy-24-norurs-4(23),12-dien-28-oic acid (7) and Saccharose(8). The structures of these compounds were elucidated using a detailed analysis of their HRESI-MS, 1D and 2D NMR spectroscopic data. Some of these compounds were evaluated in vitro for their antimicrobial activities against a wide range of microorganisms. The results showed that none of them possess noticeable activity.
    VL  - 2
    IS  - 6
    ER  - 

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Author Information
  • Department of Organic chemistry Faculty of Science University of Yaounde I, Yaounde, Cameroon

  • Department of Organic chemistry Faculty of Science University of Yaounde I, Yaounde, Cameroon

  • Department of Organic chemistry Faculty of Science University of Yaounde I, Yaounde, Cameroon

  • Department of Medical Laboratory Sciences, Faculty of health Sciences Laboratory, University of Buea, SW Region, Cameroon

  • Department of Medical Laboratory Sciences, Faculty of health Sciences Laboratory, University of Buea, SW Region, Cameroon

  • Department of Chemistry and Physics Southeastern Louisiana University, Hammond, USA

  • Department of Organic chemistry Faculty of Science University of Yaounde I, Yaounde, Cameroon

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